defibrotide

Definition / meaning of defibrotide

A polydeoxyribonucleotide with antithrombotic, thrombolytic, and fibrinolytic properties. Defibrotide induces the release of prostaglandin 12 and reduces the expression of adhesion molecules on endothelial cells, thereby interfering with platelet and leukocyte adhesion to the endothelium.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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