dendritic cell-MART-1 peptide vaccine

Definition / meaning of dendritic cell-MART-1 peptide vaccine

A cancer vaccine consisting of dendritic cells harvested from a patient with cancer and pulsed or transduced with a peptide fragment of MART-1 (melanoma antigen recognized by T-cells), an antigen expressed by melanoma cells. When the altered dendritic cells are returned to the patient, they stimulate the host immune system to mount a cytotoxic T-lymphocyte immune response against tumor cells expressing MART-1.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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