4-hydroxytamoxifen

Definition / meaning of 4-hydroxytamoxifen

A tamoxifen metabolite with both estrogenic and anti-estrogenic effects. 4-hydroxytamoxifen has a higher affinity for the estrogen receptor than tamoxifen, and functions as an antagonist in breast cancer cells.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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