autologous dinitrophenyl-modified ovarian cancer vaccine

Definition / meaning of autologous dinitrophenyl-modified ovarian cancer vaccine

A cancer vaccine consisting of autologous ovarian cancer cell peptide antigens conjugated to the hapten 2,4-dinitrophenol (DNP) with potential immunostimulating and antineoplastic activities. Administration of autologous dinitrophenyl-modified ovarian cancer vaccine may induce a cytotoxic T-lymphocyte (CTL) response against ovarian cancer cells. DNP conjugation may enhance the immunogenicity of weakly immunogenic antigens.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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