autologous lymphoma cell / autologous dendritic cell electrofusion hybrid vaccine

Definition / meaning of autologous lymphoma cell / autologous dendritic cell electrofusion hybrid vaccine

A cell-based cancer vaccine consisting of hybrid cells created by electrofusing autologous dendritic cells (DCs) and autologous lymphoma cells with potential immunostimulating and antitumor activities. Upon administration, autologous lymphoma cell/autologous dendritic cell electrofusion hybrid vaccine may stimulate the immune system to mount a specific cytotoxic T-lymphocyte (CTL) response against specific autologous lymphoma-associated antigens, resulting in lymphoma cell apoptosis.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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